Published Work

Immune evasion in HPV− head and neck precancer–cancer transition is driven by an aneuploid switch involving chromosome 9p loss

2021 - Proceedings of the National Academy of Sciences 118 (19) e2022655118. https://doi.org/10.1073/pnas.2022655118

Bianchi JJ*, Zhao X*, Mays JC, Davoli T

*equal contribution

2020 - Current Opinion in Cell Biology (63): 135-143. https://doi.org/10.1016/j.ceb.2020.01.005

Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns

Sack LM, Davoli T, Li MZ, Li Y, Xu Q, Naxerova K, Wooten EC, Bernardi RJ, Martin TD, Chen T, Leng Y, Liang AC, Scorsone KA, Westbrook TF, Wong KK, Elledge SJ

2018 -  Cell 173 (2): 499-514.

A genetic interaction analysis identifies cancer drivers that modify EGFR dependency

Liao S, Davoli T, Leng Y, Li MZ, Xu Q, Elledge SJ

2017 - Genes Dev 31 (2): 184-196.

Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy

Davoli T, Uno H, Wooten EC, Elledge SJ

2017 - Science, 355 (6322).

Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover

Davoli T, Mengwasser KE, Duan J, Chen T, Christensen C, Wooten EC, Anselmo AN, Li MZ, Wong KK, Kahle KT, Elledge SJ

2016 - Genes Dev 30 (24): 2684-2695.

Sources of Error in Mammalian Genetic Screens

Sack LM, Davoli T, Xu Q, Li MZ, Elledge SJ

2016 - G3 (Bethesda) 6 (9): 2781-90.

A primary melanoma and its asynchronous metastasis highlight the role of BRAF, CDKN2A, and TERT

Hosler GA, Davoli T, Mender I, Litzner B, Choi J, Kapur P, Shay JW, Wang RC

2015 - J Cutan Pathol 42 (2): 108-17.

Comprehensive identification of host modulators of HIV-1 replication using multiple orthologous RNAi reagents.

Zhu J, Davoli T, Perriera JM, Chin CR, Gaiha GD, John SP, Sigiollot FD, Gao G, Xu Q, Qu H, Pertel T, Sims JS, Smith JA, Baker RE, Maranda L, Ng A, Elledge SJ, Brass AL

2014 - Cell Rep 9 (2): 752-66.

Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome

Davoli T, Xu AW, Mengwasser KE, Sack LM, Yoon JC, Park PJ, Elledge SJ

2013 - Cell 155 (4): 948-62.

STOP gene Phactr4 is a tumor suppressor

Solimini NL, Liang AC, Xu C, Pavlova NN, Xu Q, Davoli T, Li MZ, Wong KK, Elledge SJ

2013 - PNAS 110 (5): E407-14.

Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells

Davoli T, de Lange T

2012 - Cancer Cell 21(6): 765-76.

The causes and consequences of polyploidy in normal development and cancer

Davoli T, de Lange T.

2011 - Annu Rev Cell Dev Biol 27: 585-610. Review.

Persistent telomere damage induces bypass of mitosis and tetraploidy

Davoli T, Denchi EL, de Lange T

2010 - Cell 141(1): 81-93.

Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma

Bonetti P, Davoli T, Sironi C, Amati B, Pelicci PG, Colombo E

2008 - J Cell Biol 182(1): 19-26.