What are the causes and consequences of genomic copy number alterations (i.e. aneuploidy) in cancer? How does aneuploidy affect patients’ response to therapy, especially immuno-therapy? How do protein complexes form in normal cells and how is this process affected by aneuploidy?
These are among the main questions our lab is interested in. To answer these questions, we utilize a variety of experimental and computational approaches, from large-scale genetic screens in human cells, to prediction of survival in cancer patients.